PRESIDENT ENDOCRINE TECHNOLOGY, LLC NY, New York, United States
Abstract Text: The Problem: Vascular complications of diabetes contribute to major economic social burden of $ 412.9 Billions in USA (Parker et al “Economic Costs of Diabetes in the U. S. in 2022” in Diabetes Care, ADA Statement (doi.org/10.2337/dci23-0085) Immune pathogenesis: The Recent advances in Genomics and Fundamentals of Immunology pertains to the Factor H and how it interacts with glycation abnormalities in the host to cause immune system dysfunction and vascular complications of diabetes (de Boer ECW, van Mourik AG and Jongerius I (2020) Therapeutic Lessons to be Learned From the Role of Complement Regulators as Double-Edged Sword in Health and Disease. Front. Immunol. 11:578069.doi: 10.3389/fimmu.2020.578069 and Reily C. et al, Glycosylation in health and disease, Nature Reviews - Nephrology, Vol. 15, June 2019, 346-366). Our Work: 80 % of complement dysfunction is attributed to "C3 Amplification Loop"that cause explosive vascular damage in diabetes. A method to inhibit C3 amplification loop is detailed with sulfonic polymer that may contribute to prevention of vascular complications and its therapy in future.
