W128 - Inhibition of Vascular Occlusive Crisis in Sickle Cell Disease

Abstract Text: Problem: The sickling of red blood cells contribute to hyper activation of alternate complement system. This contributes to major morbidity and mortality of vascular occlusive crisis.(Lombardi Et Al. in “Factor H interferes with adhesion of Sickle red cells to vascular endothelium: a novel disease-modulating molecule” Haematologica 2019; Volume 104 (5) :919-929).
Proposed Solution: Since 80% or more complement activation occur at C3 amplification loop, inhibition of this loop will lead to complement inhibition and reduce severity of vascular crisis and its related costs.
Our Work: We have developed an ultra small molecule of sulfonic polymer that act as inhibitor of Factor H, Factor B and Factor D. This will contribute to downstream inhibition of vascular crisis. Appropriate formulation strategy will provide alternate cost-effective solution to reduce morbidity and mortality related to Sickle cell related vascular occlusive crisis and its exuberant cost (Patent pending Kumar shah "IMMUNOTHERAPY OF SICKLE CELL DISEASE(SCD) WITH VASSO OCCLUSIVE (VOCs) CRISIS" 12/26/2023). Available for review if requested.