Although IL-9 was first described in the late 1980s, its regulation and functions are still not well defined. Initially thought to be a mast cell and T cell growth factor, IL-9 was subsequently reclassified as a type 2 cytokine after extensive data implicated it in atopic dermatitis, food allergy, and allergic asthma. More recently, work has implicated IL-9 as a major player in autoimmunity and antitumor immunity. New endotype-based classification systems have led many leaders in the field to speculate that “IL-9-high” endotypes have clinically relevant translational applications to precision medicine treatments of allergic, autoimmune, and malignant conditions. This has led to a renaissance of papers defining beneficial and pathogenic functions of IL-9 in disease. This symposium will focus on recent developments in IL-9 biology including a role for IL-9 in pregnancy and the function of IL-9 in allergic disease.
Organizing Society The International Cytokine and Interferon Society
Session Chairs: Mark Kaplan, PhD Professor and Chair, Department of Microbiology and Immunology Indiana University
Daniella Schwartz, MD Assistant Professor, Division of Rheumatology and Clinical Immunology, Departments of Medicine and Immunology University of Pittsburgh
Session Agenda 3:30 PM - 3:45 PM A Novel Mechanism for Preterm Labor and Birth Driven by IL-9 at the Maternal-Fetal Interface Nardhy Gomez-Lopez, PhD Professor, Department of Obstetrics and Gynecology Washington University at St. Louis
3:45 PM - 4:00 PM IL-9-producing CD4 T cells in cancer immunotherapy Lionel Apetoh, PhD Professor, Department of Microbiology and Immunology Indiana University
4:00 PM - 4:15 PM Epigenetic Control of IL-9 in Health and Disease Daniella Schwartz, MD Assistant Professor, Division of Rheumatology and Clinical Immunology, Departments of Medicine and Immunology University of Pittsburgh
4:15 PM - 4:30 PM Cooperative Roles of IL-1 and IL-2 in the Differentiation and Function of IL-9-secreting CD4 T cells Matthew Olson, PhD Assistant Professor, Department of Biology Purdue University
4:30 PM - 4:45 PM Lineage Markers for Th9 cells: the PKA/PKIB Pathway Paula Licona Limon, PhD Associate Professor, Instituto de Fisiologia Celular Universidad Nacional Autónoma de México (UNAM)
4:45 PM - 5:00 PM Allergen Induces IL9 Expression in Pathogenic Airway Th2 cells in Asthma Josalyn Cho, MD Associate Professor, Department of Internal Medicine-Pulmonary, Critical Care and Occupational Medicine University of Iowa
