Group leader, senior researcher
Nantes Université / INSERM / CR2TI
Nantes, France
Dr. Giraud is a French INSERM permanent Senior Researcher. After his post-doctorate at Harvard Medical School and Broad Institute of MIT and Harvard under the supervision of Drs. Christophe Benoist and Diane Mathis, he established his own research group at Cochin Institute in a lab he co-headed from 2013 to 2017. In 2017, he joined the CR2TI in Nantes where he coordinates research on central immunological tolerance using molecular and cellular approaches combined with transcriptional and epigenetic techniques (RNA-seq/ ATAC-seq/ Chip-seq) and advanced bioinformatics. His main research interest is the control of self-antigen expression by AIRE in the thymus and the impact of its deregulation on the outcome of the multi-organ autoimmune disease APECED in humans and Aire-KO animal models. He also leads research on iPSc-derived thymic organoids to support T cell development in vitro for therapeutical applications in APECED and other autoimmune diseases. He has authored 30 publications in renowned peer-reviewed journals.
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