Associate Professor
University of Pennsylvannia
Philadelphia, Pennsylvania, United States
Montserrat Anguera, PhD
Associate Professor
University of Pennsylvania
Dr. Anguera received her B.A. from UCSD in Chemistry and her Ph.D. from Cornell University in Biochemistry, Molecular and Cellular Biology. Her postgraduate studies were completed at Massachusetts General Hospital/Harvard University, where she developed her interest in X-Chromosome Inactivation. Her laboratory studies epigenetic gene regulation that underlies sex differences in immune-mediated diseases. Her current research investigates how gene expression from the X-chromosome is regulated in the immune system, and how these mechanisms become altered in autoimmune diseases exhibiting a sex-bias. Her lab discovered a novel and dynamic mechanism of X-Chromosome Inactivation maintenance specific to female lymphocyte activation, and how perturbations in these pathways contribute to female-biased systemic autoimmune disorders.
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Mechanisms That Contribute Towards Female-biased Autoimmunity: X-chromosome Inactivation
Friday, June 21, 2024
9:00 AM – 9:30 AM PT