University of Cincinnati
Dr. Sing Sing Way’s research is focused on reproductive and developmental immunology with the long term goal of improving pregnancy outcomes and the health of infants. His laboratory pioneered tools for tracking immune components with fetal-specificity, and utilized these tools to reveal fundamental insights on how pregnancy immunologically works. This includes distinctions between immune tolerance versus rejection driving the pathogenesis of pregnancy complications and how mothers immunological remember their babies as a basis for how prior pregnancy impacts the susceptibility of women to complications in future pregnancies. His group showed hypo-responsiveness of neonatal immune cells reflects of active suppression, as opposed to immaturity, and the importance of suppression allowing babies to tolerate first commensals. Integrating the maternal-fetal dyad, he showed the importance of microchimeric cells naturally transferred between mothers and babies in optimizing reproductive outcomes, and how antibodies are structurally changed by pregnancy to expand their protective scope upon vertical transfer. He is the founding Director for the Center for Inflammation and Tolerance at Cincinnati Children’s Hospital; and Principal Investigator for the March of Dimes Ohio Collaborative on Prematurity Research. His leadership role in these areas has been recognized by the Howard Hughes Medical Institute, NIH Director’s Pioneer award, and the inaugural recipient of the Drukier Prize in Children’s Health research, and Burroughs Wellcome Fund Investigator in Infectious Disease Pathogenesis Research.
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Immunology Learned from Mothers and Babies
Thursday, June 20, 2024
10:00 AM - 10:30 AM PT
