Assistant Professor
Duke University, Marcus Center for Cellular Cures, North Carolina, United States
Anthony (Tony) Filiano is an assistant professor at Duke University in the Department of Neurosurgery. The Filiano lab is investigating how cell interactions at the borders of the CNS regulate immune surveillance. In recent years, our appreciation of the meninges as a hub for neuroimmune communication has greatly increased and we now know that many classical immune processes take place in the meninges just outside the CNS. The meninges house a full complement of immune cells and lymphatic vessels that drain CNS generated antigens and antigen presentation cells to lymph nodes. Work from the Filiano lab is uncovering novel pathways that regulate immune cell trafficking to the meninges and how immune signaling pathways, such as the IFN-/STAT1 pathway, play important roles in maintaining brain homeostasis. Additionally, the lab is investigating how overactivation of these pathways contribute to CNS autoimmune diseases, like multiple sclerosis, and aim to develop novel cell-based therapeutics to limit CNS inflammation and promote remyelination.
Disclosure information not submitted.
Unique Aspects of IFN-γ/STAT1 Signaling in Neurons
Friday, June 21, 2024
2:40 PM - 3:05 PM PT
