Head of Immunometabolism and Inflamamtion Lab
Centro de Biologia Molecular Severo Ochoa
MARIA MITTELBRUNN is the Head of Immunometabolism & Inflammation lab at Molecular Biology Center “Severo Ochoa” (Madrid, Spain) since 2017. Her research goal is to identify new strategies to target immune cells for boosting systemic resilience to inflammaging, cellular senescence and age-related multimorbidity. She has obtained funding from the major European and Spanish funding organizations, including an European Research Council Starting Grant in 2016, and Consolidator Grant in 2022.
Among the more important discoveries from her lab:
1. Demonstration that mimicking age-associated mitochondrial dysfunction in T cells does not only recapitulate immunosenescence, but causes a general, body-wide deterioration of health with multiple aging-related features
2. Decoding the molecular mechanisms by which aged T cells contribute to inflammaging and age-related diseases
3. The above studies in her laboratory have allowed them to propose new therapeutic targets to delay age-related multimorbidity and to reverse aortic aneurysms and prevent sudden death due to aortic dissections
Her international leadership in the field is endorsed by having been an "Invited Speaker" at more than 60 conferences and international congresses in the last 5 years, including Cell Symposia, Gordon Conferences, Cold Spring Harbor Conferences, EMBO workshops, Keystone Symposium, and participating as a keynote speaker on several occasions.
She has been awarded with Doctoral thesis Extraordinary Prize (2006), L’Oréal UNESCO for Women in Science (2015), and BANCO SABADELL AWARD for Biomedical Research (2022), Royal Spanish Academia of Science (2023) for young researchers among others.
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Immunometabolism at the Crossroads Between Inflammation and Aging
Friday, June 21, 2024
3:20 PM – 3:45 PM PT
